Hirota’s direct method is one of the most effective method in dealing with nonlinear integrable equations. It was shown that most of the integrable nonlinear PDEs could be transformed into bilinear equations, which are in fact some algebraic identities satisfied by determinants or pfaffians. In this talk, I’ll generalize the original direct method into the noncommutative setting by using the technique of quasi-determinant developed by Gelfand et al. Some reduction technique in noncommutative setting will also be discussed if time permits.